Treatment with combined administration of vitamins, amino acids, antioxidants and essential metals. Cadmium toxicity may result from disturbance in plant metabolism as a consequence of disturbance in the uptake and translocation of mineral nutrients. A toxicological profile for cadmium, draft for public comment was released in september 2008. Evidence on developmental and reproductive toxicity of. Cadmium is one of the most toxic heavy metals in our environment having a very strong ability to accumulate in body organs, especially in kidney. Protective effects of myoinositol and selenium on cadmium. Cadmium metabolism and toxicity in rats after long. Comparison of the toxicity of inorganic and liverincorporated cadmium. The experiment was conducted in the course of 5 weeks. Pure cadmium is a silverwhite, lustrous metal, but cadmium in this form is not common in the environment.
It is usually found as a mineral combined with other elements such as oxygen cadmium oxide, chlorine cadmium chloride, or sulfur cadmium sulfate, cadmium sulfide. Most often, results from studies using the first three approaches have indicated multiple functions of mt in cell biology. The present study was conducted to estimate the protective role of grape seed oil gso against cadmium chloride cdcl 2 induced toxicity in male mice. A metallomic approach based on sizeexclusion chromatography sec coupled to inductively coupled plasmamass spectrometry icpms and multidimensional chromatography separation based on sec coupled to affinity fourth international symposium on metallomics, oviedo, spain. The present study aimed to investigate the mechanisms of cadmium. The present study investigates the possibility that phenobarbital could affect cadmium mortality and distribution of cadmium among various organs in mice. Cadmium cd has been reported to reduce male fertility, impair reproductive capacity, and play a major role in the pathogenesis of infertility.
Most cases of cadmium toxicity are due to chronic exposure. Various forms of cadmium poisoning have been documented in the literature. Although body lengths of newborn mice were similar, cadmium exposed mice in the 100 and 500 nm groups had lower body weights compared with the control group see figure s1a,b. Sexdependent effects of cadmium exposure in early life on. Cadmium toxicity in mus musculus mice based on a metallomic. Thus it can be concluded from the results of the present study that lycopene showed marked protective effects against cadmium induced toxicity in mice. Detoxification of cadmium with edta and other chelators is possible and.
Humans are susceptible to cd toxicity primarily through the ingestion of contaminated food or water and. Accumulation of p53 via downregulation of ube2d family. Protective effects of lactobacillus plantarum ccfm8610. May 12, 2008 cadmium toxicity sources of additional information. Protective role of lycopene against cadmium induced. Ninety mice were divided into prevention and therapy groups.
Selenium and lcarnitine ameliorate reproductive toxicity. Pdf effect of acute toxicity of cadmium in mice kidney. Cadmium is a widespread environmental pollutantused in industries, has been associated with reproductive abnormalities in male swiss mice. Biodistribution and acute toxicity of cadmium free quantum dots with different surface functional groups in mice following intratracheal inhalation guimiao lin 1, ting chen2, yongning pan3, zhiwen yang, li li,2, kentye yong4, xiaomei wang1, jie wang1, yajing chen 1, wenxiao jiang 1, shuting weng1, xiaorui huang, jiajie kuang, gaixia xu2 1. Mar 01, 2017 thus, the offspring were exposed to cadmium from the initial stage of life. Iron regulatory protein 1 is not an early target of cadmium. Our previous study confirmed the ability of lactobacillus plantarum ccfm8610 to protect against acute cadmium cd toxicity in mice. It is widely distributed in humans, the chief sources of contamination being cigarette smoke, welding, and contaminated food and beverages. In the prevention groups, ccfm8610 was administered at 109 cfu once daily for 7 days, followed by a single oral dose of cadmium chloride at 1. Fundamental and applied toxicology 10, 635647 1988 cadmiuminduced ovarian toxicity in hamsters, mice, and rats sabine rehmi and michael p. Effect of acute toxicity of cadmium in mice kidney cells. Protective effect of phenobarbital on cadmium toxicity in. Chronic cadmium cd exposure can induce renal toxicity.
Due to its low permissible exposure in humans, overexposure may occur even in situations where trace quantities of cadmium are found. Seven studies in rats and mice wherein cadmium salts acetate, sulfate, chloride were administered orally have shown no evidence of carcinogenic response. Plasma antioxidants changes after acute cadmium intoxication in. Cadmium exposure of female mice impairs the meiotic maturation. The present study has been undertaken to evaluate the protective efficacy of garlic extract on cadmium induced toxicity in brain and. Whilst in leucocytes count, the cadmium treated group exhibited a statistically significant rise in the number p sep 10, 2006 cadmium cd has been in industrial use for a long period of time. The present study was done to determine the genotoxicity and cytotoxicity in kidneys of rats exposed to cadmium. There is sufficient evidence of carcinogenicity in rats and mice by inhalation and intramuscular and subcutaneous injection.
Acute poisoning, depending on the mode of exposure, can cause lifethreatening respiratory or gastrointestinal symptoms in the absence of immediate supportive therapy, while chronic toxicity, mostly through occupational exposure may lead to renal failure, osteomalacia and increase the risk for cardiovascular disease. Waalkes tumor pathology and pathogenesis section and inorganic carcinogenesis section, laboratory of comparative carcinogenesis, division of cancer etiology, national cancer institutefrederick cancer research facility, frederick. Experimental mice were divided into two groups and exposed to cd for 8 weeks via drinking. Iron regulatory protein 1 is not an early target of cadmium toxicity in mice, but it is sensitive to cadmium stress in a human epithelial cell line. Cadmium can be absorbed by the oral and inhalation routes of exposure. It is most often encountered in the earths crust combined with chlorine cadmium chloride, oxygen cadmium oxide, and sulfur cadmium sulfide. Hepatoprotective effect of oleuropeinrich extract from. Cadmium is a heavy metal that is incredibly toxic to the human body and everpresent in our environment. The mechanism of cadmium toxicity on the female reproductive. Cadmium induced ovarian toxicity in hamsters, mice, and rats. Thus, the offspring were exposed to cadmium from the initial stage of life. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Cadmium is an element with atomic symbol cd, atomic number 48, and atomic weight 112.
This study was designed to evaluate the protective effects of ccfm8610 against chronic cd toxicity in mice and to gain insights into the protection mode of this strain. Because it is a nondegradable, cumulative pollutant, continued releases are of global concern atsdr 2008. In the prevention groups, ccfm8610 was administered at 10 9 cfu once daily for 7 days, followed by a single oral dose of cadmium chloride at. Protective effect of quercetin on cadmium induced oxidative toxicity on germ cells in male mice tongliang bu, yuling mi, weidong zeng, and caiqiao zhang key laboratory of animal epidemic etiology and immunological prevention of the ministry of agriculture, department of veterinary medicine, college of animal sciences. Sep2010 7 1 executive summary 2 3 cadmium c d is a metal used in a variety of consumer and industrial materials with a 4 high percentage use d in the production of nickelcadmium batteries and in electroplating. Eightyfour male mice were divided into 12 groups seven mice each. Pdf protective efficacy of streptococcus thermophilus. Specific health effects of a given hazardous compound are reported by type. Gender differences in susceptibility, at lower exposure, are uncertain, but some data indicate that cd has estrogenic effects and affects female offspring 8.
This study evaluated the protective effects of lactobacillus plantarum ccfm8610, a selected probiotic with good cadmium binding capacity, against acute cadmium toxicity in mice. Pdf cadmium cd is a highly toxic heavy metal, wide occupational and an environmental pollutant, affecting human health. Effect of the chelating agent sodium tripolyphosphate on. Cadmium is a heavy metal of considerable toxicity with destructive impact on most organ systems. Cadmium transporters in the kidney and cadmiuminduced. Cadmium is a highly toxic heavy metal, since it causes deleterious effects in organisms at low levels of exposure. Most cadmium used in the united states is extracted during the production of other metals like. Cadmium is toxic in moderate doses and is a potent.
Cadmium behavior and toxicity cadmium and other metals released from mining sites can contaminate drinking and other water. Cadmium cd is a toxic heavy metal that enters the environment through various anthropogenic sources, and inhibits plant growth and development. Feb 01, 2017 this study examined the protective effects of probiotic supplementation against cadmium induced toxicity in the rat. However, persuading evidence from in vivo characterization is lacking. This study examined the protective effects of probiotic supplementation against cadmiuminduced toxicity in the rat.
Toxic impacts are discussed and appear to be proportional to body burden of cadmium. Cadmium cd is a harmful pollutant which mainly affects the liver and kidney. Research paper biodistribution and acute toxicity of. Cadmium is one of the most toxic heavy metals in our.
The toxicity of cadmium and resulting hazards for human health. Absorption and retention of cadmium are known to be influenced by species, age, pregnancy, and by the adequacy of other components of the diet. May 11, 20 download printerfriendly version pdf 490 kb. Toxic effect of acute cadmium and lead exposure in rat. Timedependent toxicity of cadmium telluride quantum dots on liver and kidneys in mice. All soils and rocks, including coal and mineral fertilizers, contain some cadmium.
Cadmiuminduced ovarian toxicity in hamsters, mice, and rats. Cadmium is one major pollutant that is highly toxic to animals and humans. Male icr mice weighing 3035 g were given 30 mgkg phenobarbital, sc,once a day for 5 days, followed by a single ip injection of a sublethal dose of a heavy metal, as. Rehm s, waalkes mp 1988 cadmiuminduced ovarian toxicity in hamsters, mice, and rats. This edition supersedes any previously released draft or final profile. This may be a synopsis of the full weightofevidence narrative. Cadmium toxicity on swiss mice and spermatogenesis manoj kumar panda lecturer in zoology, u. Pdf cadmium distribution and toxicity in tissues of small rodents. Although body lengths of newborn mice were similar, cadmiumexposed mice in the 100 and 500 nm groups had lower body weights compared with the control group see figure s1a,b. It is 5 also in pigments used in plastics, ceramics and glasses and is used as a stabilizer for polyvinyl 6. It targets many systems of the body and can cause a multitude of different symptoms.
Protective effects of natural antioxidant supplementation. Cadmium cd is a metal that can cause severe acute or chronic toxicity in humans. The toxicity of cadmium and resulting hazards for human. Cadmiuminduced ovarian toxicity in hamsters, mice, and. Cadmium is used extensively in electroplating, although the nature of the operation does not generally lead to overexposure. Evidence on developmental and reproductive toxicity of cadmium. Mechanism of cadmium poisoning on testicular injury in mice. Male rats n30, kept in standard conditions were used in this study. Mt a is a storehouse for zinc, b is a freeradical scavenger, and c protects against cadmium cd toxicity. Effect of acute toxicity of cadmium in mice kidney cells masoomeh masoomi karimi 1, moslem jafari sani 2, ali zaree mahmudabadi 3, asma jafari sani 4, seyed reza khatibi 5 received. Sep2010 7 1 executive summary 2 3 cadmium c d is a metal used in a variety of consumer and industrial materials with a 4 high percentage use d in the production of nickel cadmium batteries and in electroplating.
Cadmium retention is generally higher in women rather than men 8. In cd renal toxicity, p53 is thought to be involved. Animals were randomly divided into seven groups n 10. The protective effects of probiotic bacteria on cadmium. Lycopene which have antioxidant properties showed the ability to reverse the alterations in hematological parameters and thus ameliorated the toxic effects of cadmium. Cadmium deficiency has not been convincingly shown in humans.
In the prevention groups, ccfm8610 was administered at 109 cfu once daily for 7 days, followed by a single oral dose of cadmium chloride at. Fundamental and applied toxicology 10, 635647 1988 cadmium induced ovarian toxicity in hamsters, mice, and rats sabine rehmi and michael p. Chronic, lowlevel cadmium exposure can affect a variety of organs, with the kidneys and bones being the principal targets. Cadmium toxicity sources of additional information. Protective effect of quercetin on cadmiuminduced oxidative. Cadmium toxicity what diseases are associated with chronic exposure to cadmium. The effects of cadmium on the female genital tract of syrian hamsters cnrgh, of four mouse strains balbcanncr, dba2ncr, c57bl 6ncr, nfsncr, and two rat strains f344ncr and wfncr were studied by light microscopy after a single. Its serious toxicity moved into scientific focus during the middle of the last century.
Cadmium cd has been in industrial use for a long period of time. The effects of stpp on acute cd toxicity, development of cdinduced liver necrosis, rate of cd transport, distribution of cd among organs, and cd. Cadmium cd is a widespread industrial and environmental pollutant that may cause harmful effects on humans and animals. Cadmium cd is an important inorganic toxicant in the environment which impacts on human health. Timedependent toxicity of cadmium telluride quantum dots. The effects of cadmium on the female genital tract of syrian hamsters cnrgh, of four mouse strains balbcanncr, dba2ncr, c57bl 6ncr, nfsncr, and two rat strains f344ncr and wfncr were studied by light microscopy after a single sc injection. Cadmium toxicity in plants and role of mineral nutrients. Nov 06, 2012 this study evaluated the protective effects of lactobacillus plantarum ccfm8610, a selected probiotic with good cadmium binding capacity, against acute cadmium toxicity in mice. However, studies using mttransgenic and null mice have not strongly supported the first two proposed. Cadmium toxicity occurs when high levels of the element are accumulated in. Waalkes tumor pathology and pathogenesis section and inorganic carcinogenesis section, laboratory of comparative carcinogenesis, division of cancer etiology, national cancer institutefrederick cancer research facility, frederick, maryland 2170110. Timedependent toxicity of cadmium telluride quantum dots on.
Hepatoprotective effect of oleuropeinrich extract from olive. Cadmium is a heavy metal that is toxic to humans and the reproductive system. Cadmium toxicity almost always goes undetected by most traditional physicians. Protective role of garlic against cadmium toxicity in rats. Cadmium is a naturally occurring toxic metal with common exposure in industrial workplaces, plant soils, and from smoking. Cadmium toxicity in plants and role of mineral nutrients in. Protective effects of natural antioxidant supplementation on. Wistar rats were randomly divided into five groups.
The mechanism by which sodium tripolyphosphate stpp increases cadmium toxicity after sc administration was investigated in mice after a dose of cd 30. Cadmium is a trace element and transitional metal that is not believed to play a role in higher biologic systems or in human nutrition. Pdf estimation of grape seed oil alleviative role on. Next, 100 nm cadmium was employed to establish the ldc mouse model for earlylife exposure.
140 1393 269 798 491 253 1026 625 1243 983 1416 12 247 1030 54 114 855 898 142 975 598 1154 1498 893 1140 823 611 92 1098 279 350 10 1412 512 677 1173 1228 646 289