Invivo gastric antiulcer activity of syringin phenyl propanoid glucoside studied in different ulcer induced experimental rat models c. Evaluation of antiulcer activity of whole plant extract of malvastrum. The anti gastric ulcer activity of pisonia aculeata leaf extracts in pylorus ligation model is evident from its significant reduction in gastric volume, free acidity, total acidity, ulcer score and increase in p h when compared to that of standard drug. In order to enhance the use of plants as potential sources of new therapeutic agents and to advocate. Consequently we have evaluated the anti ulcer activity of meaf. Many medicinal plants exhibit antiulcer activity and found useful in the treatment of peptic ulcer. The compounds which were isolated fro the twig of plats were subjected to screening for antiulcer activity. A large number of populations are now relying on these medicinal plants as they are relatively safe, cheap and have no adverse effects. Medicinal plants and traditional medicines in africa. Total alkaloids, tannin content, and antiulcer assay of.
Antiulcer activity of indigenous plant operculina turpethum linn. Fam family, t tree, h herb, c climber, s shrub plant common name maturity period botanical name or family parts used average price rs. The extract is nontoxic even at relatively high concentrations. The major causes include generation of free radicles, decrease in mucosal defense. Ulcer was induced by administering 1 ml of absolute histamine acid phosphate solution 50 mg base i. Evaluation of antiulcer activity of the leaf extract of osyris. Pdf antiulcer activity of some indian medicinal plants. Medicinal plants as antiulcer agents t lakshmi srinivas, s mohana lakshmi, s neelufar shama, g koteswara reddy. Dglucopyranosyloxyethane was isolated natutally first time from the annona squamosa twigs.
This third volume contains an additional collection of 32 monographs describing the quality control and use of selected medicinal plants. Antiinflammatory and antioxidant activities of medicinal. This was done to verify its ethno medicinal use in the treatment of ulcer. Evaluation of free radical scavenging and antiulcer. Traditionally the plant is reported to have antiulcer activity.
Over the last few years, rechears have aimed at identifying and validating plant derived substances for the treatment of various diseases. Exploring indian medicinal plants for antiulcer activity p. A number of drugs including proton pump inhibitors and h 2. Palit abstract peptic ulcer disease pud is a serious gastrointestinal disorder that requires a well tar geted therapeutic strategy. The current study aimed to investigate the polyphenol content in some of these medicinal plants and to. The potential medicinal plants used in ulcer in spite of being one of the wellknown medicinal plants used in indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of some medicinal plants are very scarce. Currently medicinal plants have become the paramount source of drug discovery in research for treating diverse form of diseases including cancer. Dhanapalan college of arts and science, chennai, india.
A total of 25 plants belonging to different species of leguminosea family. Plants as natural antiinflammatory agents unlike modern allopathic drugs which are single active components that target one specific pathway. Evaluation of the antiulcer properties of castor plants. The in vivo bioassay was conducted on formalin mosaddek et al.
The petroleum ether 250mgkg and aqueous extracts 250mgkg of bark of boswellia serrata plant showed significant antiulcer activity as evidenced by the data obtained. Medicinal plants as antiulcer agents pharmacognosy journal. This association of medicinal plants and cancer needs further research and experimentation in order to develop and design anticancer drugs. Who published volume 1 of the medicinal plants, containing. A potential of some medicinal plants as an antiulcer agents ncbi. Antiulcer activity of pisonia aculeata on pylorus ligation. The final volume of franz eugen kohlers medizinalpflanzen or medicinal plants published in 1887 features red algae and fungi too. Herbal drugs with anti ulcer activity dilpreet kaur, a.
In addition, inappropriate use wrong plant parts, dose, frequency, route of administra tion, preparation, etc. The structures and biological activities of the bark and leaf pectins were therefore compared in order to make recommendation on plant part substitution as debarking can damage or even kill the tree. Active principles of antiulcer activity are flavonoids, terpenoids and tannins. Vidya ignatius, 1 madhusudhanan narayanan, 1 venkataraman subramanian, 2 and balasubramanian maruthaiveeran periyasamy 2 1 department of pharmacology, sathyabama university dental college and hospital, sathyabama university, jeppiaar nagar, rajiv gandhi road, chennai. Introduction increasing role of the who monographs on selected medicinal plants over the past two decades, there has been a tremendous increase in the use of herbal medicine. Ag is a famous medicinal plant widely used for its medicinal properties for the treatment of many diseases such as dysentery, hepatitis. Gymnema sylvestre is a highly valued ethno pharmacologically important medicinal plant used currently in many polyherbal formulations due to its potential antidiabetic activity and other health benefits. Drugs of plant origin are gaining popularity and are being investigated for a number.
Acidic heteroxylans from medicinal plants and their antiulcer activity. Abstract the recent pharmacological studies showed that many medicinal plants exerted a wide range of beneficial gastrointestinal effects. Evaluation of antiulcer activity of the main phenolic acids found in brazilian green propolis. It has been documented that a great amount of traditional knowledge about the uses of medicinal plant.
Aroma is offering an ineffable support to the folk medicine, which is a traditional medicine for the treatment of ulcers in india. In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Gastric fluid total acidity and free acidity were estimated in pylorus ligated rats. Medicinal plants used in folk medicine contain a wide range of substances that can prevent and treat many diseases. Physalis minima has shown antiinflammatory and analgesic action in animals. Medicinal plants naturally synthesize and accumulate some secondary metabolites, like alkaloids, sterols, terpenes, flavonoids, saponins, glycosides, cyanogenics, tannins, resins. Date ddmm a potential of some medicinal plants as an. Antiulcer activity was evaluated by measuring ulcer index and percentage of ulcer healing. Components in the methanolic extract of plants revealed by hplc analysis. Antiulcer activity of ficus religiosa leaf ethanolic extract.
An illustrated, scientific and medicinal approach appears to be a medical compendium of plants intended as a guide and reference resource for professionals in the field. Hplc analysis of phenolic compounds was done using methanol and water as mobile phase at 254 nm. The mechanism involved in production of antiulcer activity of the plant is due to its antioxidant, antiinflammatory, mucus. But the nature lovers that we are, we have left them in. Medicinal plants containing active chemical constituents are useful in prevention and treatment of. Treatment of peptic ulcers depends on using a number of synthetic drugs that reduce. The mechanism involved in production of antiulcer activity by plant leaf extract is cytoprotective mechanism as well as antisecretory 8.
Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. The petroleum ether 250mgkg and aqueous extracts 250mgkg of bark of boswellia serrata plant showed significant antiulcer activity as evifindings also confirm the antiulcer activity of boswellia serrata bark extracts in albino rats. See previous posts for volume 1, volume 2 and volume 3 with associated book and source details. The antigastric ulcer activity of 90% ethanolic extract at 200mgkg is. As high as 80% of the world population depends on plantderived medicines for the first line of. Ittiyavirah masters thesis medicine pharmacology publish your bachelors or masters thesis, dissertation, term paper or essay.
The medicinal chemistry course adme adsorption, distribution, metabolism and excretion of drugs drugreceptor interactions development of drugs screening techniques combinatorial chemistry d. The literature revealed that many medicinal plants. The present study was carried out to analyze the antistress, antiallergic, and antiulcer activity of the bioactive. In this context, the use of medicinal plants for the prevention and treatment of different pathologies is in continuous expansion worldwide 10. Evaluation of antiulcer activity of boswellia serrata bark. Antiulcer activity of ethanolic extract of salvadora. Acute toxicity was conducted with a single oral dose of 5gkg. We had studied at the medical college, trivandrum, properties of nimbidine, the bitter amorphous. Structures, and immunomodulating and antiulcer activities. In case of the rest of the medicinal plants the 2008, serotonin and egg. But these drugs are expensive and are likely to produce more side effects when compared to herbal medicines. Histological studies revealed that these medicinal plants did not show any acute toxicity. Antioxidant activity and constituents of propolis collected in various areas of china. We studied the antiulcer activity and acute toxicity of some medicinal plants.
Indian medicinal plants, peptic ulcer, ocimum sanctum. Pdf acidic heteroxylans from medicinal plants and their. Antinociceptive activity was evaluated in acetic acidinduced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated. Antinociceptive and antiulcer activities of pycnanthus. Gastric ulcers are located in the stomach, characterized by pain. The extract at 400 mg kg1 and 600 mg kg1 showed significant 0.
Generating an epub file may take a long time, please be patient. Swingle is a decidous tree belonging to simaroubaceae family and widely distributed in asia and north australia. It has mucoprotective activity and gastric antisecretary when compared with that of reference drugs. Exploring indian medicinal plants for antiulcer activityexploring indian medicinal plants for antiulcer activity we read with interest the article exploring indian medicinal plants for anti ulcer activity indian j pharmacol 2006. There are various medicinal plants and their extracts containing active chemical constituents, e. Various herbal plants and plants extracts have significant antiulcer activity in animal models. The observed activity is these plants is attributed with the presence of flavonoids, alkaloids, terpenoids, tannins, saponins, and phenolic acids 4, 10, 15, 21. The total alkaloids content tac was evaluated according to the chloride colometric method in which atropine was. The white mulberry has a long history of medicinal use in. We conclude that plant extracts are potential sources of new antiulcer agents. The antiulcer activity of esil 150, 300 and 600 mgkg p.
Analgesic, antipyretic and antiulcer activities of ailanthus. The journal of medicinal plants research jmpr is an open access journal that provides rapid publication weekly of articles in all areas of medicinal plants research, ethnopharmacology, fitoterapia, phytomedicine etc. An aphrodisiac is defined as an agent that arouses sexual desire. The information is recorded in plant scientific name, family, part used, route of administration, dose given, method used. The antiulcer activity of the poly herbal formulation composed of the leaf extracts from lantana camara, annona muricata, kalanchoe pinnata was evaluated in stress induced ulcer model in rats. Thus, there is an urgent need to identify more effective and safe antiulcer agent. Antiinflammatory and antioxidant activities of medicinal plants used by traditional healers for antiulcer treatment. A person may have both gastric and duodenal ulcers at the same time. Some of the medicinal plants with antiulcer activity journal of. Although medicinal plants are generally safe when used appropriately according to the traditional methods, some are inherently toxic.
P, 2 sri sai college of pharmacy, badhani, pathankot145001. Exploring indian medicinal plants for antiulcer activity. Rana, nidhi sharma and sunil kumar abstract a peptic ulcer is an erosion in a segment of the gastro intestinal mucosa, typically in the stomach gastric ulcer or first few centimeters of duodenum duodenal ulcer that penetrates through the muscularis mucosae. Traditional medicine and drug discovery 80% of the world population resides in developing countries 80% of people in developing countries utilize plants to meet their primary health care needs global pop. The parameters assessed were gastric volume, free acidity, total acidity, ulcer index and percentage ulcer protection. Some medicinal plants used in the treatment of ulcer. This article will be concerned only with the antiulcer and gastroprotective effects. Several researches have confirmed the efficacy of medicinal plants for the treatment of peptic ulcer disease. Antiulcer activity of different extracts of anvillea garcinii and. Phenolic compounds are commonly found in both edible. Exploring indian medicinal plants for antiulcer activity bioline. Acalypha indica can be useful in treating pneumoniae, asthma, rheumatism and several other ailments. In this present work, antiulcer effect of different extracts of physalis minima was studied in. A potential of some medicinal plants as an antiulcer agents.
The antiulcer activities effects of myrrh or commiphora molmol extract cme were assessed in rats. In spite of being one of the wellknown medicinal plants used inindian traditional medicine to treat several ailments, studies pertaining to the pharmacologicalproperties of some medicinal plants are very scarce. Therefore, efforts should be directed towards isolation and characterization of the active principles and elucidation of the relationship between structure and activity. The purpose of this study was the evaluation by a chemical method of the antioxidant capacity of phenolic compounds in some algerian medicinal plants. The underlisted medicinal plants have been pharmacological reported to possess antiulcer activity as previously compiled3435363738 39.
Antiulcer activities of commiphora molmol myrrh extract. Comparative phytochemical analysis of selected medicinal. In this context, it is largely known the folk use of medicinal plants in the treatment of gastric ulcers. To study the antiulcer activity of aqueous extract of roots of tephrosia purpurea aetp using different models of gastric and duodenal ulceration in rats. To my delight and i am sure of anyone who picks up this book, i discovered it contains nug. Invivo gastric antiulcer activity of syringin phenyl. Antiulcer screening of selected plants of plumbago species. Ayurvedic knowledge supported by modern science is necessary to isolate, characterise, and standardise the active constituents from herbal sources for antiulcer activity. These medicinal plants showed stronger antioxidant activity and content in phenolics than the common nutritional plants. The antiulcer activity of the methanolic extract of kigelia africana was evaluated in wistar albino rats. Hence several experimental studies have demonstrated that medicinal plants extracts are important sources for chemical compounds with gastroprotective activity 9. Antiulcer activity of some selected medicinal plants.
Hence, it establishes the fact that the methanol extract of antiulcer activity of acacia farnesiana l. According to traditional and ethnomedicinal claims. Phytochemical importance of medicinal plants as potential. Pdf antiulcer activity of some selected medicinal plants. The peptic ulcer is a widespread and common health problem around the world. Evaluation of antiulcer activity of moringa oleifera seed extract. Peptic ulcer, gastric ulcer, aggressive factors, defensive factors, abdominal pain, medicinal plants. Free radical scavenging activity and total phenolic compounds of. The medicinal plants have been used for treatment of illnesses and diseases, since the dawn of time.
Antioxidant activity of some algerian medicinal plants. Antiulcer activities of medicinal plants and natural products. Antiulcer activity of aetp was studied in rats in which gastric ulcers were induced by oral administration of ethanol or 0. The extract was evaluated for its free radical scavenging activity by dpph method followed by antiulcer activity using pyloric ligation, water immersion stress and nsaid indomethacin induced gastric ulcer model niu in rats. In vitro antioxidant capacity and in vivo antiulcer and. Preliminary photochemical screening of this medicinal plant identified the presence of important secondary metabolites like flavonoids and tannins which are the active principles of antiulcer activity.
Biogeographic regions see more details for peptic ulcer and, if reported, the antiulcer activity. Kg medicinal use amla t after 4th year emblica officinalis fam euphorbiaceac fruit rs 15 45kg vitamin c, cough. In pyloric ligation induced ulcer model, the studied parameters were gastric volume, ph, total acidity, free acidity, and ulcer index whereas in ethanol and cysteamine induced ulcer model, the ulcer index was determined for severity of ulcers. Antiulcer activities of medicinal plants and natural. Antiulcer antiulcer allophylus pdf antiulcer therapeutics has wider market globally citing the fact of prevalence of. The plant leaf extracts reported antiulcer activity in experimentallyinduced gastric ulcers in rats. Antiulcer screening of selected plants of plumbago species and the effect of plumbagin in gastric cell lines studies of plumbago plants for ulcer and inflammation treatment dr. Antiulcerogenic activity of ethanol extract of the bark from. Gastric ulcers are located in the stomach, characte rized by pain. Medicinal plants provide an effective and safer way in disease management.
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